Kinetic resolution in asymmetric epoxidation using iminium salt catalysis
journal contributionposted on 25.02.2015, 11:36 by Philip C. Bulman Page, Louise F. Appleby, Yohan Chan, David P. Day, Benjamin BuckleyBenjamin Buckley, Alexandra M.Z. Slawin, Steven M. Allin, Michael J. McKenzie
The first reported examples of kinetic resolution in epoxidation reactions using iminium salt catalysis are described, providing up to 99% ee in the epoxidation of racemic cis-chromenes.
This investigation has enjoyed the support of the EPSRC, the University of East Anglia, Charnwood Molecular Ltd, and the ERDF (IS:CE-Chem & INTERREG IVa Programme 4061). We acknowledge the support of The Royal Society (PCBP: Industry Fellowship). We are also indebted to the EPSRC Mass Spectrometry Unit, Swansea.