Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles
journal contributionposted on 2017-04-07, 14:08 authored by Pangkhi Medhi, Ololade Olatunji, Atul Nayak, Chandrateja Uppuluri, Richard T. Olsson, Buchi N. Nalluri, Diganta DasDiganta Das
Microneedle (MN) technology has emerged as an effective drug delivery system, and it has tremendous potential as a patient friendly substitute for conventional methods for transdermal drug delivery (TDD). In this paper, we report on the preparation of lidocaine-loaded biodegradable microneedles, which are manufactured from fish scale-derived collagen. Lidocaine, a common tissue numbing anaesthetic, is loaded in these microneedles with an aim of delivering the drug with controlled skin permeation. Evaluation of lidocaine permeation in porcine skin has been successfully performed using Franz diffusion cell (FDC) which has shown that the drug permeation rate increases from 2.5 to 7.5% w/w after 36 h and pseudo steady state profile is observed from 5.0 to 10.0% w/w lidocaine-loaded microneedle. Swelling experiments have suggested that the microneedles have negligible swellability which implies that the patch would stick to the tissue when inserted. The experiments on MN dissolution have depicted that the lidocaine loaded in the patch is lower than the theoretical loading, which is expected as there can be losses of the drug during initial process manufacture.
The authors wish to acknowledge the British Council, UK, and Directorate of Science and Technology (DST), India, for supporting the work. This research is supported by the International Foundation for Science IFS (Grant No. F/5544-1).
- Aeronautical, Automotive, Chemical and Materials Engineering
- Chemical Engineering
Published inAAPS PharmSciTech
CitationMEDHI, P. ... et al, 2017. Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles. AAPS PharmSciTech, 18(5), pp. 1488-1494
PublisherSpringer © American Association of Pharmaceutical Scientists
- AM (Accepted Manuscript)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
NotesThis is a post-peer-review, pre-copyedit version of an article published in AAPS PharmSciTech. The final authenticated version is available online at: http://dx.doi.org/10.1208/s12249-017-0758-5.