Mansukoski_et_al-2019-American_Journal_of_Human_Biology.pdf (1.97 MB)

Life course associations of height, weight, fatness, grip strength, and all-cause mortality for high socioeconomic status Guatemalans

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posted on 02.05.2019, 09:57 by Liina Mansukoski, Will Johnson, Katherine Brooke-Wavell, J. Andres Galvez-Sobral, L.R. Furlan, Tim J. Cole, Barry Bogin
Objectives: The objective of this study was to investigate the association between physical growth in pre-adult life with five outcomes at age 64-76: weight, body mass index, estimated body fat percentage, hand grip strength and mortality. Methods: Super-Imposition by Translation and Rotation (SITAR) growth curves of 40,484 Guatemalan individuals aged 3-19 years were modelled for the parameters of size, timing and intensity (peak growth velocity, e.g. cm/year) of height, weight, body mass index, and grip strength. Associations between the SITAR parameters and old age outcomes were tested using linear and binary logistic regression for a follow-up sample of high socioeconomic status (SES) Guatemalans, of whom 50 were aged 64-76 years old at re-measurement and 45 died prior to the year 2017. Results: SITAR models explained 69-98% of the variance in each outcome, with height the most precise. Individuals in the follow-up sample who had a higher BMI before age 20 years had higher estimated body fat (B=1.4 CI -0.02-2.8) and BMI (B=1.2, CI 0.2-2.2) at the ages 64-76 years. Those who grew slower in height but faster in weight and BMI before age 20 years, had higher BMI and body fat later in life. Conclusions: These findings highlight the importance of a life course perspective on health and mortality risk. Childhood exposures leading to variation in pre-adult growth may be key to better understanding health and mortality risks in old age.

Funding

LM is supported by a PhD Grant from the Finnish Osk. Huttunen Foundation. Digitisation of the UVG Study data records was supported by both the UVG and the Healthy Birth, Growth and Development knowledge integration (HBGDki) programme of the Bill & Melinda Gates Foundation (contract OPP1125811) awarded to BB. WJ is supported by a UK Medical Research Council (MRC) New Investigator Research Grant (MR/P023347/1) and acknowledges support from the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University, and the University of Leicester. TJC is funded by MRC research grant MR/R010692/1.

History

School

  • Sport, Exercise and Health Sciences

Published in

American Journal of Human Biology

Volume

31

Issue

4

Pages

e23253

Citation

MANSUKOSKI, L.M. ... et al., 2019. Life course associations of height, weight, fatness, grip strength, and all-cause mortality for high socioeconomic status Guatemalans. American Journal of Human Biology, 31 (4), e23253.

Publisher

Wiley © The Authors

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

01/05/2019

Publication date

2019-05-15

Copyright date

2019

Notes

This is an Open Access article. It is published by Wiley under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

ISSN

1042-0533

Language

en

Licence

Exports