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Lipid metabolism after mild cold stress in persons with a cervical spinal cord injury

journal contribution
posted on 12.05.2022, 15:32 authored by Kazunari Nishiyama, Yoshi-ichiro Kamijo, Jan Van-Der-Scheer, Tokio Kinoshita, Vicky Goosey-TolfreyVicky Goosey-Tolfrey, Sven Hoekstra, Yukihide Nishimura, Takashi Kawasaki, Takahiro Ogawa, Fumihiro Tajima
Study design: Experimental study. Objectives: To compare lipid metabolism in individuals with a cervical spinal cord injury (SCIC) and able-bodied (AB) persons in response to mild cold stress.Settings: Laboratory of Wakayama Medical University, Japan. Methods: Nine males with SCIC and 11 AB wore a water-perfusion suit in a supine position. Following 30-min rest thermoneutrality, the whole body was cooled by perfusing 25°C water through the suit for 15-20 minutes (CS). Blood samples were collected before, immediately, and 60 (post-CS60) and 120 minutes after CS (post-CS120). Concentrations of serum free fatty acid ([FFA]s), total ketone bodies ([tKB]s), insulin ([Ins]s) and plasma adrenaline ([Ad]p), noradrenaline ([NA]p) and glucose ([Glc]p) were assessed. Results: [Ad]p in SCIC were lower than AB throughout the study (p=0.0002) and remained largely unchanged in both groups. [NA]p increased after cold stress in AB only (p<0.0001; GxT p=0.006). [FFA]s increased by 62% immediately after cold stress in SCIC (p=0.0028), without a difference between groups (p=0.65). [tKB]s increased by 69% at post-CS60 and 132% at post-CS120 from the start in SCIC with no differences between groups (p=0.54). [Glc]p and [Ins]s were reduced in SCIc only (GxT p=0.003 and p=0.001, respectively). Conclusion: These data indicate that mild cold stress acutely elevates lipid and ketone body metabolism in persons with SCIc, despite the presence of sympathetic dysfunction.

Funding

Joint Usage/Research Center of Sport for Persons with Impairments, authorized by the Ministry of Education, Culture, Sports, Science and Technology in Japan,

Nachikatsuura Research Foundation (L1221)

History

School

  • Sport, Exercise and Health Sciences

Published in

Spinal Cord

Publisher

Springer Nature

Version

AM (Accepted Manuscript)

Rights holder

© The Author(s), under exclusive licence to International Spinal Cord Society

Publisher statement

This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41393-022-00788-9

Acceptance date

28/02/2022

Publication date

2022-05-04

Copyright date

2022

ISSN

1362-4393

eISSN

1476-5624

Language

en

Depositor

Prof Vicky Tolfrey. Deposit date: 26 February 2022