Spinal Cord 2022 Lipid metabolism after mild cold stress.pdf (435.43 kB)
Download fileLipid metabolism after mild cold stress in persons with a cervical spinal cord injury
journal contribution
posted on 2022-05-12, 15:32 authored by Kazunari Nishiyama, Yoshi-ichiro Kamijo, Jan Van-Der-Scheer, Tokio Kinoshita, Vicky Goosey-TolfreyVicky Goosey-Tolfrey, Sven Hoekstra, Yukihide Nishimura, Takashi Kawasaki, Takahiro Ogawa, Fumihiro TajimaStudy design: Experimental study. Objectives: To compare lipid metabolism in individuals with a cervical spinal cord injury (SCIC) and able-bodied (AB) persons in response to mild cold stress.Settings: Laboratory of Wakayama Medical University, Japan. Methods: Nine males with SCIC and 11 AB wore a water-perfusion suit in a supine position. Following 30-min rest thermoneutrality, the whole body was cooled by perfusing 25°C water through the suit for 15-20 minutes (CS). Blood samples were collected before, immediately, and 60 (post-CS60) and 120 minutes after CS (post-CS120). Concentrations of serum free fatty acid ([FFA]s), total ketone bodies ([tKB]s), insulin ([Ins]s) and plasma adrenaline ([Ad]p), noradrenaline ([NA]p) and glucose ([Glc]p) were assessed. Results: [Ad]p in SCIC were lower than AB throughout the study (p=0.0002) and remained largely unchanged in both groups. [NA]p increased after cold stress in AB only (p<0.0001; GxT p=0.006). [FFA]s increased by 62% immediately after cold stress in SCIC (p=0.0028), without a difference between groups (p=0.65). [tKB]s increased by 69% at post-CS60 and 132% at post-CS120 from the start in SCIC with no differences between groups (p=0.54). [Glc]p and [Ins]s were reduced in SCIc only (GxT p=0.003 and p=0.001, respectively). Conclusion: These data indicate that mild cold stress acutely elevates lipid and ketone body metabolism in persons with SCIc, despite the presence of sympathetic dysfunction.
Funding
Joint Usage/Research Center of Sport for Persons with Impairments, authorized by the Ministry of Education, Culture, Sports, Science and Technology in Japan,
Nachikatsuura Research Foundation (L1221)
History
School
- Sport, Exercise and Health Sciences
Published in
Spinal CordVolume
60Issue
11Pages
978–983Publisher
Springer NatureVersion
- AM (Accepted Manuscript)
Rights holder
© The Author(s), under exclusive licence to International Spinal Cord SocietyPublisher statement
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41393-022-00788-9Acceptance date
2022-02-28Publication date
2022-05-04Copyright date
2022ISSN
1362-4393eISSN
1476-5624Publisher version
Language
- en