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Long-term effect of gender-affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study

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journal contribution
posted on 13.08.2020, 10:14 by Zoe Aldridge, Shireen Patel, Boliang Guo, Elena Nixon, Walter Pierre Bouman, Gemma WitcombGemma Witcomb, Jon Arcelus
Background Cross-sectional studies show that transgender people are more likely than cisgender people to experience depression and anxiety before Gender Affirming Hormone Treatment (GAHT). However, the effect of GAHT on mental health in transgender people, and the role of other factors that may have a predictive effect, is poorly explored. Objectives Using a longitudinal methodology, this study investigated the effect of 18 months GAHT on depression and anxiety symptomatology and the predictors on mental health outcomes in a large population of transgender people. Materials and Methods Participants (n=178) completed a socio-demographic questionnaire, the Hospital Anxiety and Depression Scale (HADS), the Multidimensional Scale of Perceived Social Support (MSPSS) and the Autism Spectrum Quotient Short Version (AQ-short) at pre-assessment (T0) and at 18 months after initiation of GAHT (T1). Results From T0 to T1, symptomatology was significantly decreased for depression (P <0.001) and non-significantly reduced for anxiety (P=0.37). Scores on the MSPSS predicted reduction in depression, while scores on the AQ-short predicted reduction in anxiety. Discussion GAHT reduces symptoms of depression which are predicted by having higher levels of social support. Although anxiety symptoms also reduce the changes are not significant and high levels of anxiety still remain post GAHT. Conclusions These results highlight the important mental health benefits of GAHT. Support services (professional, third sector or peer-support) aiming at increasing social support for transgender individuals should be made available.

Funding

National Institute for Health Research (NIHR) Applied Research Collaboration East Midlands (ARC EM)

NIHR Research for Patient Benefit (RfPB)

Nottinghamshire Healthcare NHS Foundation Trust

History

School

  • Sport, Exercise and Health Sciences

Published in

Andrology

Volume

9

Issue

6

Pages

1808-1816

Publisher

Wiley

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Wiley under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

05/08/2020

Publication date

2020-09-03

Copyright date

2020

ISSN

2047-2919

eISSN

2047-2927

Language

en

Depositor

Dr Gemma Witcomb. Deposit date: 10 August 2020