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Low-cost and effective fabrication of biocompatible nanofibers from silk and cellulose-rich materials

journal contribution
posted on 05.04.2016, 14:47 by Susana Guzman-Puyol, Jose A. Heredia-Guerrero, Luca Ceseracciu, Hadi Hajiali, Claudio Canale, Alice Scarpellini, Roberto Cingolani, Ilker S. Bayer, Athanassia Athanassiou, Elisa MeleElisa Mele
Here, we show the production of nanofibrous mats with controlled mechanical properties and excellent biocompatibility by combining fibroin with pure cellulose and cellulose-rich parsley powder agro-waste. To this end, trifluoroacetic acid was used as a common solvent for all of the involved biomaterials, achieving highly homogeneous blends that were suitable for the electrospinning technique. Morphological analysis revealed that the electrospun composite nanofibers were well-defined and defect-free, with a diameter in the range of 65−100 nm. Mechanical investigations demonstrated that the fibrous mats exhibited an increased stiffness when pure fibroin was combined with cellulose, whereas they possessed an increased flexibility when the parsley waste was added to fibroin. Lastly, the produced mats were highly biocompatible, as demonstrated by the promoted proliferation of fibroblast cells. The characteristics of the hybrid fibroin−cellulose nanofibers, in terms of nanoscale topography, mechanical properties, and biocompatibility, are attractive and potentially applicable in the biomedical sector.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

ACS Biomaterials Science & Engineering

Volume

2

Issue

4

Pages

526-534

Citation

GUZMAN-PUYOL, S. ...et al., 2016. Low-cost and effective fabrication of biocompatible nanofibers from silk and cellulose-rich materials. ACS Biomaterials Science & Engineering, 2(4), pp. 526–534.

Publisher

© American Chemical Society

Version

P (Proof)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

14/03/2016

Publication date

2016-03-24

Copyright date

2016

Notes

This paper is in closed access.

ISSN

2373-9878

eISSN

2373-9878

Language

en