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Low temperature cell pausing: an alternative short-term preservation method for use in cell therapies including stem cell applications

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journal contribution
posted on 06.03.2014, 15:56 authored by Nathalie J. Robinson, Andy Picken, Karen CoopmanKaren Coopman
Encouraging advances in cell therapies have produced a requirement for an effective short-term cell preservation method, enabling time for quality assurance testing and transport to their clinical destination. Low temperature pausing of cells offers many advantages over cryopreservation, including the ability to store cells at scale, reduced cost and a simplified procedure with increased reliability. This review will focus on the importance of developing a short-term cell preservation platform as well highlighting the major successes of cell pausing and the key challenges which need addressing, to enable application of the process to therapeutically relevant cells.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

ROBINSON, N.J., PICKEN, A. and COOPMAN, K., 2014. Low temperature cell pausing: an alternative short-term preservation method for use in cell therapies including stem cell applications. Biotechnology Letters, 36 (2), pp. 201 - 209.

Publisher

© Springer

Version

AM (Accepted Manuscript)

Publication date

2014

Notes

This article was published in the journal, Biotechnology Letters [© Springer] and the definitive version is available at: http://dx.doi.org/10.1007/s10529-013-1349-5

ISSN

0141-5492

Language

en