Manufacturability, mechanical properties, mass-transport properties and biocompatibility of triply periodic minimal surface (TPMS) porous scaffolds fabricated by selective laser melting
journal contributionposted on 10.08.2020, 14:50 by Shuai Ma, Qian Tang, Xiaoxiao Han, Qixiang Feng, Jun Song, Rossitza Setchi, Ying Liu, Yang Liu, Athanasios Goulas, Daniel Engstrom, Yau Tse, Ni Zhen
Selective laser melting is a promising additive manufacturing technology for manufacturing porous metallic bone scaffolds. Bone repair requires scaffolds that meet various mechanical and biological requirements. This paper addresses this challenge by comprehensively studying the performance of porous scaffolds. The main novelty is exploring scaffolds with different porosities, verifying various aspects of their performance and revealing the effect of their permeability on cell growth. This study evaluates the manufacturability, mechanical behaviour, permeability and biocompatibility of gyroid scaffolds. In simulations, mechanical behaviour and permeability exhibited up to 56% and 73% accuracy, respectively, compared to the experimental data. The compression and permeability experiments showed that the elastic modulus and the permeability of the scaffolds were both in the range of human bones. The morphological experiment showed that manufacturing accuracy increased with greater designed porosity, while the in vitro experiments revealed that permeability played the main role in cell proliferation. The significance of this work is improving the understanding of the effect of design parameters on the mechanical properties, permeability and cell growth of the scaffolds, which will enable the design of porous bone scaffolds with better bone-repair effects.
National Natural Science Foundation of China (Grant No: 51975073, No. 51805052)
Fundamental Research Funds for the Central Universities (No. 2018CDXYJX0019)
Chongqing Science and Technology Bureau (No. cstc2018 jszx-cyzdX0102)
- Aeronautical, Automotive, Chemical and Materials Engineering
- Mechanical, Electrical and Manufacturing Engineering