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Analytical Science Advances - 2023 - Ong - Mass Sportrometry An annual look back at applications of mass spectrometry in.pdf (1.88 MB)

Mass Sportrometry: An annual look back at applications of mass spectrometry in sport and exercise science

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posted on 2023-05-23, 15:53 authored by Marilyn LY Ong, Christopher Green, Samantha RowlandSamantha Rowland, Liam HeaneyLiam Heaney

Research in sport and exercise science (SES) is reliant on robust analyses of biomarker measurements to assist with the interpretation of physiological outcomes. Mass spectrometry (MS) is an analytical approach capable of highly sensitive, specific, precise, and accurate analyses of a range of biomolecules, many of which are of interest in SES including, but not limited to, endogenous metabolites, exogenously administered compounds (e.g. supplements), mineral ions, and circulating/tissue proteins. This annual review provides a summary of the applications of MS across studies investigating aspects related to sport or exercise in manuscripts published, or currently in press, in 2022. In total, 93 publications are included and categorized according to their methodologies including targeted analyses, metabolomics, lipidomics, proteomics, and isotope ratio/elemental MS. The advantageous analytical opportunities afforded by MS technologies are discussed across a selection of relevant articles. In addition, considerations for the future of MS in SES, including the need to improve the reporting of assay characteristics and validation data, are discussed, alongside the recommendation for selected current methods to be superseded by MS-based approaches where appropriate. The review identifies that a targeted, mostly quantitative, approach is the most commonly applied MS approach within SES, although there has also been a keen interest in the use of ‘omics’ to perform hypothesis-generating research studies. Nonetheless, MS is not commonplace in SES at this time, but its use to expand, and possibly improve, the analytical options should be continually considered to exploit the benefits of analytical chemistry in exercise/sports-based research. Overall, it is exciting to see the gradually increasing adoption of MS in SES and it is expected that the number, and quality, of MS-based assays in SES will increase over time, with the potential for 2023 to further establish this technique within the field. 

Funding

Ministry of Higher Education Malaysia

Universiti Sains Malaysia Post-Doctoral Fellowship

Loughborough University

ADM Biopolis

History

School

  • Sport, Exercise and Health Sciences

Published in

Analytical Science Advances

Volume

4

Issue

3-4

Pages

60-80

Publisher

Wiley

Version

  • VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. See https://creativecommons.org/licenses/by/4.0/ for more information.

Acceptance date

2023-03-12

Publication date

2023-03-31

Copyright date

2023

eISSN

2628-5452

Language

  • en

Depositor

Dr Liam Heaney. Deposit date: 10 April 2023

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