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Mass transfer resistance in a liquid-phase microextraction employing a single hollow fiber under unsteady-state conditions

journal contribution
posted on 03.10.2012, 13:04 by Ksenija R. Kumric, Goran VladisavljevicGoran Vladisavljevic, Jelena S. Dordevic, Jan Ake Jonsson, Tatjana M. Trtic-Petrovic
In this study, the mass transport resistance in liquid-phase microextraction (LPME) in a single hollow fiber was investigated. A mathematical model has been developed for the determination of the overall mass transfer coefficient based on the acceptor phase in an unsteady state. The overall mass transfer coefficient in LPME in a single hollow fiber has been estimated from time-dependent concentration of extracted analyte in the acceptor phase while maintaining a constant analyte concentration in the donor phase. It can be achieved either using a high volume of donor to acceptor phase ratio or tuning the extraction conditions to obtain a low-enrichment factor, so that the analyte concentration in the sample is not significantly influenced by the mass transfer. Two extraction systems have been used to test experimentally the developedmodel: the extraction of Lu(III) from a buffer solution and the extraction of three local anesthetics from a buffer or plasma solution. The mass transfer resistance, defined as a reciprocal values of the mass transfer coefficient, was found to be 1.2 × 103 cm−1 min for Lu(III) under optimal conditions and from 1.96 to 3.3 × 103 cm−1 min for the local anesthetics depending on the acceptor pH and the hydrophobicity of the drug.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

KUMRIC, K.R. ... et al, 2012. Mass transfer resistance in a liquid-phase microextraction employing a single hollow fiber under unsteady-state conditions. Journal of Separation Science, 35(18), pp.2390-2398.

Publisher

© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Version

NA (Not Applicable or Unknown)

Publication date

2012

Notes

This article is closed access. It was published in the Journal of Separation Science: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1615-9314

ISSN

1615-9306

eISSN

1615-9314

Language

en