Reilly_Final_manuscript_Su et al (2016).pdf (1.84 MB)
Mathematical modelling and experimental validation of a novel periodic flow crystallization using MSMPR crystallizers
journal contribution
posted on 2016-10-17, 14:01 authored by Qinglin Su, Chris RiellyChris Rielly, Keddon A. Powell, Zoltan NagyZoltan NagyThe challenges of insufficient residence time for crystal growing and transfer line blockage in conventional continuous MSMPR operations are still not well addressed. Periodic flow crystallization is a novel method whereby controlled periodic disruptions are applied to the inlet and outlet flows of an MSMPR crystallizer in order to increase its residence time. A dynamic model of residence time distribution in an MSMPR crystallizer was first developed to demonstrate the periodic flow operation. Besides, process models of periodic flow crystallizations were developed with an aim to provide a better understanding and improve the performance of the periodic flow operation, wherein the crystallization mechanisms and kinetics of the glycine-water system were estimated from batch cooling crystallization experiments. Experiments of periodic flow crystallizations were also conducted in single- / three-stage MSMPR crystallizers to validate the process models and demonstrate the advantages of using periodic flow operation in MSMPR stages.
Funding
This work was performed within the UK EPSRC funded project (EP/K014250/1) ‘Intelligent Decision Support and Control Technologies for Continuous Manufacturing and Crystallization of Pharmaceuticals and Fine Chemicals’ (ICT-CMAC).
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
AIChE JournalVolume
63Issue
4Pages
1313-1327Citation
SU, Q. ...et al., 2016. Mathematical modelling and experimental validation of a novel periodic flow crystallization using MSMPR crystallizers. AIChE Journal, 63 (4), pp. 1313–1327.Publisher
© American Institute of Chemical Engineer. Published by WileyVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2016-09-19Publication date
2016-10-06Copyright date
2017Notes
This is the peer reviewed version of the following article: SU, Q. ...et al., 2016. Mathematical modelling and experimental validation of a novel periodic flow crystallization using MSMPR crystallizers. AIChE Journal, 63 (4), pp. 1313–1327., which has been published in final form at http://dx.doi.org/10.1002/aic.15510. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.ISSN
1547-5905Publisher version
Language
- en