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Mathematical modelling and experimental validation of a novel periodic flow crystallization using MSMPR crystallizers

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journal contribution
posted on 17.10.2016 by Qinglin Su, Chris Rielly, Keddon A. Powell, Zoltan Nagy
The challenges of insufficient residence time for crystal growing and transfer line blockage in conventional continuous MSMPR operations are still not well addressed. Periodic flow crystallization is a novel method whereby controlled periodic disruptions are applied to the inlet and outlet flows of an MSMPR crystallizer in order to increase its residence time. A dynamic model of residence time distribution in an MSMPR crystallizer was first developed to demonstrate the periodic flow operation. Besides, process models of periodic flow crystallizations were developed with an aim to provide a better understanding and improve the performance of the periodic flow operation, wherein the crystallization mechanisms and kinetics of the glycine-water system were estimated from batch cooling crystallization experiments. Experiments of periodic flow crystallizations were also conducted in single- / three-stage MSMPR crystallizers to validate the process models and demonstrate the advantages of using periodic flow operation in MSMPR stages.

Funding

This work was performed within the UK EPSRC funded project (EP/K014250/1) ‘Intelligent Decision Support and Control Technologies for Continuous Manufacturing and Crystallization of Pharmaceuticals and Fine Chemicals’ (ICT-CMAC).

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

AIChE Journal

Citation

SU, Q. ...et al., 2016. Mathematical modelling and experimental validation of a novel periodic flow crystallization using MSMPR crystallizers. AIChE Journal, 63 (4), pp. 1313–1327.

Publisher

© American Institute of Chemical Engineer. Published by Wiley

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

19/09/2016

Publication date

2016-09-22

Notes

This is the peer reviewed version of the following article: SU, Q. ...et al., 2016. Mathematical modelling and experimental validation of a novel periodic flow crystallization using MSMPR crystallizers. AIChE Journal, 63 (4), pp. 1313–1327., which has been published in final form at http://dx.doi.org/10.1002/aic.15510. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

ISSN

1547-5905

Language

en

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