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Measuring the flow functions of pharmaceutical powders using the Brookfield powder flow tester and Freeman FT4

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journal contribution
posted on 16.11.2021, 11:23 by Mark LeaperMark Leaper
This study examined the feasibility of combining data from different powder flow testers to determine the flow function characteristics of pharmaceutical powders. The Brookfield PFT and Freeman FT4 can measure flow function over different scales of consolidation load but were found to be most complementary with CRM limestone powder and lactose. The brittle behaviour of Easytab particles at higher loads made obtaining repeatable results with the FT4 challenging. By using the method of Wang et al., where the flow function coefficient ffc is plotted against the dimensionless cohesion C* (measured cohesion Ta divided by the initial compaction I), a plot was formed which could be used to predict the behaviour of other systems, which compared well with previous studies.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Processes

Volume

9

Issue

11

Publisher

MDPI AG

Version

VoR (Version of Record)

Rights holder

© The authors

Publisher statement

This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

11/11/2021

Publication date

2021-11-13

Copyright date

2021

eISSN

2227-9717

Language

en

Depositor

Dr Mark Leaper. Deposit date: 15 November 2021

Article number

2032