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Mesenchymal stem cell-derived extracellular vesicles may promote breast cancer cell dormancy
journal contribution
posted on 2019-01-17, 14:38 authored by Jake Casson, Owen DaviesOwen Davies, Carol-Anne Smith, Matthew J. Dalby, Catherine C. BerryDisseminated breast cancer cells have the capacity to metastasise to the bone marrow and
reside in a dormant state within the mesenchymal stem cell (MSC) niche. Research has
focussed on paracrine signalling factors, such as soluble proteins, within the microenvironment.
However, it is now clear extracellular vesicles (EVs) secreted by resident MSCs into this
microenvironment also play a key role in the initiation of dormancy. Dormancy encourages
reduced cell proliferation and migration, whilst upregulating cell adhesion, thus retaining the
cancer cells within the bone marrow microenvironment. Here, MCF7 breast cancer cells were
treated with MSC-derived EVs, resulting in reduced migration in 2D and 3D culture, with
reduced cell proliferation and enhanced adhesion, collectively supporting cancer cell dormancy.
Funding
The authors would like to reference funding from the BBSRC for this work, grant reference number BB/L008661/1.
History
School
- Sport, Exercise and Health Sciences
Published in
Journal of Tissue EngineeringVolume
9Pages
204173141881009 - 204173141881009Citation
CASSON, J. ... et al., 2018. Mesenchymal stem cell-derived extracellular vesicles may promote breast cancer cell dormancy. Journal of Tissue Engineering, 9, pp. 1-7.Publisher
© The Authors. Published by SAGE PublicationsVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/Acceptance date
2018-10-10Publication date
2018Notes
This is an Open Access Article. It is published by Sage under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/ISSN
2041-7314eISSN
2041-7314Publisher version
Language
- en