Davies_2041731418810093.pdf (557.24 kB)
Download fileMesenchymal stem cell-derived extracellular vesicles may promote breast cancer cell dormancy
journal contribution
posted on 2019-01-17, 14:38 authored by Jake Casson, Owen DaviesOwen Davies, Carol-Anne Smith, Matthew J. Dalby, Catherine C. BerryDisseminated breast cancer cells have the capacity to metastasise to the bone marrow and
reside in a dormant state within the mesenchymal stem cell (MSC) niche. Research has
focussed on paracrine signalling factors, such as soluble proteins, within the microenvironment.
However, it is now clear extracellular vesicles (EVs) secreted by resident MSCs into this
microenvironment also play a key role in the initiation of dormancy. Dormancy encourages
reduced cell proliferation and migration, whilst upregulating cell adhesion, thus retaining the
cancer cells within the bone marrow microenvironment. Here, MCF7 breast cancer cells were
treated with MSC-derived EVs, resulting in reduced migration in 2D and 3D culture, with
reduced cell proliferation and enhanced adhesion, collectively supporting cancer cell dormancy.
Funding
The authors would like to reference funding from the BBSRC for this work, grant reference number BB/L008661/1.
History
School
- Sport, Exercise and Health Sciences