Highton et al. Microparticles and Exercise in Clinical Populations - Final accepted Version.pdf (436.32 kB)
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Microparticles and exercise in clinical populations

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journal contribution
posted on 17.11.2017, 16:04 by Patrick Highton, Naomi Martin, Alice C. Smith, James O. Burton, Nicolette BishopNicolette Bishop
Microparticles (MPs) are shed membrane vesicles released from a variety of cell types in response to cellular activation or apoptosis. They are elevated in a wide variety of disease states and have been previously measured to assess both disease activity and severity. However, recent research suggests that they also possess bioeffector functions, including but not limited to promoting coagulation and thrombosis, inducing endothelial dysfunction, increasing pro‐inflammatory cytokine release and driving angiogenesis, thereby increasing cardiovascular risk. Current evidence suggests that exercise may reduce both the number and pathophysiological potential of circulating MPs, making them an attractive therapeutic target. However, the existing body of literature is largely comprised of in vitro or animal studies and thus drawing meaningful conclusions with regards to health and disease remains difficult. In this review, we highlight the role of microparticles in disease, comment on the use of exercise and dietary manipulation as a therapeutic strategy, and suggest future research directions that would serve to address some of the limitations present in the research to date.

Funding

The research was supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre and the Stoneygate Trust.

History

School

  • Sport, Exercise and Health Sciences

Published in

Exercise Immunology Review

Citation

HIGHTON, P.J. ... et al, 2018. Microparticles and exercise in clinical populations. Exercise Immunology Review, 24, pp. 46-58.

Publisher

Association for the Advancement of Sports Medicine

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

09/11/2017

Publication date

2018

Notes

This paper was accepted for publication in the journal Exercise Immunology Review and the definitive published version is available at http://www.isei.dk/index.php?pageid=3

ISSN

1077-5552

Language

en

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