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Modification of the surface nanotopography of implant devices: A translational perspective

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journal contribution
posted on 25.11.2021, 11:29 by K Harawaza, Brian CousinsBrian Cousins, Paul RoachPaul Roach, Antonio Fernandez-MatoAntonio Fernandez-Mato
There is an increasing need for the development of superior, safe, and more sophisticated implants, especially as our society historically has been moving towards an increasingly aging population. Currently, most research is being focused on the next generation of advanced medical implants, that are not only biocompatible but have modified surfaces that direct specific immunomodulation at cellular level. While there is a plethora of information on cell-surface interaction and how surfaces can be nanofabricated at research level, less is known about how the academic knowledge has been translated into clinical trials and commercial technologies. In this review, we provide a clinical translational perspective on the use of controlled physical surface modification of medical implants, presenting an analysis of data acquired from clinical trials and commercial products. We also evaluate the state-of-the-art of nanofabrication techniques that are being applied for implant surface modification at a clinical level. Finally, we identify some current challenges in the field, including the need of more advanced nanopatterning techniques, the comparatively small number of clinical trials and comment on future avenues to be explored for a successful clinical translation.

Funding

Next Generation Manufacturing of 3D Active Surface Coatings

Engineering and Physical Sciences Research Council

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History

School

  • Science

Department

  • Chemistry

Published in

Materials Today Bio

Volume

12

Publisher

Elsevier

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

19/10/2021

Publication date

2021-10-21

Copyright date

2021

ISSN

2590-0064

Language

en

Depositor

Deposit date: 24 November 2021

Article number

100152