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Multiplexed droplet Interface bilayer formation
journal contributionposted on 2016-12-15, 13:51 authored by Nathan E. Barlow, Guido Bolognesi, Anthony J. Flemming, Nicholas J. Brooks, Laura M.C. Barter, Oscar Ces
We present a simple method for the multiplexed formation of droplet interface bilayers (DIBs) using a mechanically operated linear acrylic chamber array. To demonstrate the functionality of the chip design, a lipid membrane permeability assay is performed. We show that multiple, symmetric DIBs can be created and separated using this robust low-cost approach.
The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no 607466. This research was funded by EPSRC grants: EP/J017566/1, EP/L015498/1, EP/ J021199/1 and EP/K503733/1.
- Aeronautical, Automotive, Chemical and Materials Engineering
- Chemical Engineering
Published inLab Chip
Pages4653 - 4657
CitationBARLOW, N.E. ... et al, 2016. Multiplexed droplet Interface bilayer formation. Lab Chip, 16 (24), pp. 4653 - 4657.
PublisherRoyal Society of Chemistry
- VoR (Version of Record)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/
NotesThis is an open access article published by the Royal Society of Chemistry and distributed under the terms of the Creative Commons Attribution Licence (CC BY 3.0), https://creativecommons.org/licenses/by/3.0/