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Multiuse nanopore platform with disposable paper analytical device for the detection of heavy metal ions

journal contribution
posted on 03.12.2020, 15:03 by Imogen Heaton, Mark Platt
The pollution of heavy metal ions within the environment is a global problem. The rapid and precise removal of these contaminants can be aided by identifying and quantifying the composition of the sample. It is therefore crucial to develop effective portable analytical techniques to determine the levels of heavy metal contamination. Paper-based analytical devices (PADs) offer a low-cost method, making them an excellent platform for onsite environmental sensors. Here, we demonstrate how a PAD can be integrated into a multi-use nanopore platform. The PAD was functionalized with different recognition ligands, whose surface charge densities varied in the presence of an analyte. The surface of the PAD was placed in contact with a nanopore which exhibited ion current rectification (ICR). The extent of ICR was dependent upon the PAD’s surface charge and the presence of the analyte of interest, that is, the ICR phenomena was exaggerated or diminished indicating the presence of the metal ion in solution. We demonstrate the potential of PAD–ICR using a PAD functionalized with a peptide aptamer specific for nickel ions, allowing the detection of nickel(II) as low as 0.25 μM even in the presence of other metal ions. After any measurement, the nanopore surface can be wiped clean and reused. PAD–ICR can also be adapted as a multiplexed sensor. This is demonstrated using a PAD with three different DNA aptamers for simultaneous and specific detection of nickel, mercury, and lead ions.

Funding

Nuclear Decommissioning Authority

History

School

  • Science

Department

  • Chemistry

Published in

Industrial & Engineering Chemistry Research

Publisher

American Chemical Society (ACS)

Version

AM (Accepted Manuscript)

Rights holder

© American Chemical Society

Publisher statement

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Industrial & Engineering Chemistry Research, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.iecr.0c04806.

Acceptance date

11/11/2020

Publication date

2020-11-24

Copyright date

2020

ISSN

0888-5885

eISSN

1520-5045

Language

en

Depositor

Dr Mark Platt. Deposit date: 2 December 2020

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