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Multivalent cation induced attraction of anionic polymers by like-charged pores
journal contributionposted on 2017-11-08, 11:09 authored by Sahin Buyukdagli, Tapio Ala-NissilaTapio Ala-Nissila
© 2017 Author(s). The efficiency of nanopore-based polymer sensing devices depends on the fast capture of anionic polyelectrolytes by negatively charged pores. This requires the cancellation of the electrostatic barrier associated with repulsive polymer-pore interactions. We develop a correlation-corrected theory to show that the barrier experienced by the polymer can be efficiently overcome by the addition of multivalent cations into the electrolyte solution. Cation adsorption into the pore enhances the screening ability of the pore medium with respect to the bulk reservoir which translates into an attractive force on the polymer. Beyond a critical multivalent cation concentration, this correlation-induced attraction overcomes the electrostatic barrier and triggers the adsorption of the polymer by the like-charged pore. It is shown that like-charge polymer-pore attraction is suppressed by monovalent salt but enhanced by the membrane charge strength and the pore confinement. Our predictions may provide enhanced control over polymer motion in translocation experiments.
- Mathematical Sciences
Published inJournal of Chemical Physics
CitationBUYUKDAGLI, S. and ALA-NISSILA, T., 2017. Multivalent cation induced attraction of anionic polymers by like-charged pores. Journal of Chemical Physics, 147: 144901.
Publisher© the Authors. Published by AIP
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NotesThis article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. The following article appeared in BUYUKDAGLI, S. and ALA-NISSILA, T., 2017. Multivalent cation induced attraction of anionic polymers by like-charged pores. Journal of Chemical Physics, 147: 144901 and may be found at https://doi.org/10.1063/1.4994018