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Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes

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posted on 21.06.2022, 13:59 authored by Oliver M Shannon, Tom CliffordTom Clifford, Douglas R Seals, Daniel H Craighead, Matthew J Rossman

Aging is associated with a decline in physiological function and exercise performance. These effects are mediated, at least in part, by an age-related decrease in the bioavailability of nitric oxide (NO), a ubiquitous gasotransmitter and regulator of myriad physiological processes. The decrease in NO bioavailability with aging is especially apparent in sedentary individuals, whereas older, physically active individuals maintain higher levels of NO with advancing age. Strategies which enhance NO bioavailability (including nutritional supplementation) have been proposed as a potential means of reducing the age-related decrease in physiological function and enhancing exercise performance and may be of interest to a range of older individuals including those taking part in competitive sport. In this brief review we discuss the effects of aging on physiological function and endurance exercise performance, and the potential role of changes in NO bioavailability in these processes. We also provide a summary of current evidence for dietary supplementation with substrates for NO production — including inorganic nitrate and nitrite, L-arginine and L-citrulline — for improving exercise capacity/performance in older adults. Additionally, we discuss the (limited) evidence on the effects of (poly)phenols and other dietary antioxidants on NO bioavailability in older individuals. Finally, we provide suggestions for future research.

Funding

NuBrain: UK Consortium for Optimal Nutrition for Healthy Brain Ageing

Medical Research Council

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Nitrite Supplementation for Improving Physiological Function in Older Adults

National Institute on Aging

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Novel time-efficient inspiratory muscle strength training for lowering systolic blood pressure and improving endothelial, cerebrovascular, and cognitive function

National Heart Lung and Blood Institute

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Sodium Nitrite Supplementation for Improving Physiological Function in Patients with Chronic Kidney Disease

National Institute of Diabetes and Digestive and Kidney Diseases

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History

School

  • Sport, Exercise and Health Sciences

Published in

Nitric Oxide

Volume

125-126

Pages

31-39

Publisher

Elsevier Inc.

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

06/06/2022

Publication date

2022-06-12

Copyright date

2022

ISSN

1089-8603

Language

en

Depositor

Dr Tom Clifford. Deposit date: 14 June 2022