No influence of the fat mass and obesity-associated gene rs9939609 single nucleotide polymorphism on blood lipids in young males

The fat mass and obesity-associated gene (FTO) rs9939609 A-allele is linked to obesity and dyslipidaemia, yet the independent influence of this polymorphism on blood lipids remains equivocal. We examined the influence of the FTO rs9939609 polymorphism on fasting and postprandial blood lipids in individuals homozygous for the risk A-allele or T-allele with similar anthropometric and demographic characteristics. 12 AA and 12 TT males consumed a standardized meal after fasting overnight. Blood samples were collected at baseline (-1.5 hour [hr]), before the meal (0 hr), and for five-hours postprandially to measure lipid, glucose, and insulin concentrations. Time-averaged total area under the curve (TAUC) values (0-5 hr) were calculated and compared between genotypes. Fasting triacylglycerol (TG), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, non-esterified fatty acid (NEFA), glucose, and insulin concentrations were similar between groups (P≥0.293). TAUC for TG was similar in AAs and TTs (95% confidence interval [CI] -0.52 to 0.31 mmol/L/hr; P=0.606). Likewise, TAUC values were similar for NEFA (95% CI -0.04 to 0.03 mmol/L/hr; P=0.734), glucose (95% CI -0.41 to 0.44 mmol/L/hr; P=0.951), and insulin (95% CI -6.87 to 2.83 pmol/L/hr; P=0.395). Blood lipids are not influenced by the FTO rs9939609 polymorphism, suggesting the FTO-dyslipidaemia link is mediated by adiposity and weight management is important preventing FTO-related lipid variations.