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Obesity, metabolic health, and history of Cytomegalovirus infection in the general population
journal contribution
posted on 2016-02-22, 13:50 authored by Mark Hamer, G. David Batty, Mika KivimakiContext:Commoncommunity-acquired infections, such as cytomegalovirus (CMV),maycontribute
to the development of obesity and metabolic dysfunction, but empirical evidence is scarce. Objective: We examined the associations between CMV, obesity and metabolic characteristics in a large, general population-based sample of adults.
Design and setting: An observational study in community dwelling adults from the general population, ‘Understanding Society – the UK Household Longitudinal Study’.
Participants: 9,517 men and women (aged 52.4 ± 16.4 yrs; 55.3% female). Measures: CMV infection was measured using Immunoglobulin G (IgG) from serum. Obesity was
defined as body mass index ≥30 kg/m2. Based on blood pressure, HDL-cholesterol, triglycerides,glycated haemoglobin A1c, and C-reactive protein, participants were classified as ‘healthy’ (0 or 1 metabolic abnormality) or ‘unhealthy’ (≥2 metabolic abnormalities). Results: A positive CMV test was recorded in 47.5% of the sample. There was no association between CMV and obesity. Of the individual metabolic risk factors, CMV was positively associated with glycated haemoglobin and HDL-cholesterol. In combination, only ‘unhealthy non-obese’
participants had modestly increased odds of CMV (odds ratio compared to healthy normal weight = 1.12, 95% confidence interval 1.00 – 1.26) after adjusting for a range of variables. CMV was associated with an increased prevalence of cardiovascular diseases (odds ratio=1.67; 1.07 – 2.60) independently of obesity, metabolic risk factors, and other covariates. Conclusion: Our findings suggest a weak but statistically significant association between CMV and metabolic dysfunction in non-obese adults. This relationship appears to be masked in the obese, possibly by the effects of excess adiposity on metabolism.
History
School
- Sport, Exercise and Health Sciences
Published in
The Journal of Clinical Endocrinology & MetabolismCitation
HAMER, M., BATTY, G.D. and KIVIMAKI, M., 2016. Obesity, metabolic health, and history of Cytomegalovirus infection in the general population. The Journal of Clinical Endocrinology & Metabolism, In press.Publisher
© Endocrine SocietyVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2016Notes
This paper was accepted for publication in the journal Journal of Clinical Endocrinology and Metabolism and the definitive published version is available at http://dx.doi.org/10.1210/jc.2015-4208ISSN
0021-972XeISSN
1945-7197Publisher version
Language
- en