Observations on the modified Wenker synthesis of aziridines and the development of a biphasic system

Buckley, Benjamin; Patel, Anish P.; Wijayantha-Kahagala-Gamage, Upul

JOC Repos.pdf (352.3 kB)

Observations on the modified Wenker synthesis of aziridines and the development of a biphasic system

journal contribution

posted on 2013-03-26, 15:50 authored by Benjamin BuckleyBenjamin Buckley, Anish P. Patel, Upul Wijayantha-Kahagala-Gamage

A cheap and reliable process for the modified Wenker cyclization to afford aziridines has been achieved using biphasic conditions for a range of amino alcohol starting materials. A 100 mmol “one-pot” process has also been devised and enantiopurity of the starting amino alcohol is retained in the aziridine product.

History

School

Science

Department

Chemistry

Citation

BUCKLEY, B.R., PATEL, A.P. and WIJAYANTHA, K.G.U., 2013. Observations on the modified Wenker synthesis of aziridines and the development of a biphasic system. Journal of Organic Chemistry, 78 (3), pp.1289-1292.

Publisher

Version

AM (Accepted Manuscript)

Publication date

2013

Notes

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo302615g