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One-pot synthesis of (R)-convolutamydine A involving in situ chiral organocatalyst formation

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journal contribution
posted on 23.09.2015, 15:08 by Shengwei Wei, Bernard Schmid, Fliur Z. Macaev, Serghei N Curlat, Andrei Malkov, Svetlana B. Tsogoeva
The application of a convenient one-pot synthetic strategy, utilizing an in situ formed organocatalyst, to the enantioselective synthesis of anti-leukaemia agent (R)-convolutamydine A has been demonstrated.

Funding

S.B.T is grateful to the Interdisciplinary Center for Molecular Materials (ICMM), Erlangen Catalysis Resource Center (ECRC) and Deutsche Forschungsgemeinschaft (DFG) for research support. S.B.T. and F.Z.M. acknowledge financial support from the BMBF and AȘM (bilateral BMBF-AȘM project Ref. № MDA 08/010 and № 09.820.05.08 GF).

History

School

  • Science

Department

  • Chemistry

Published in

Asymmetric Catalysis

Volume

2

Issue

1

Pages

1 - 6 (6)

Citation

WEI, S. ... et al, 2015. One-pot synthesis of (R)-convolutamydine A involving in situ chiral organocatalyst formation. Asymmetric Catalysis, 2 (1), pp. 1 - 6.

Publisher

De Gruyter Open / © The Authors

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported (CC BY-NC-ND 3.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/3.0/

Publication date

2015

Notes

This is an Open Access article published by De Gruyter Open and licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.

DOI

eISSN

2300-4630

Publisher version

Language

en

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Categories

Keywords

Chiral drug synthesisOrganocatalysisOne-pot reactionsAmino alcoholsReductionAldol reaction

Licence

CC BY-NC-ND 3.0

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