One-pot synthesis of (R)-convolutamydine A involving in situ chiral organocatalyst formation
journal contributionposted on 23.09.2015, 15:08 by Shengwei Wei, Bernard Schmid, Fliur Z. Macaev, Serghei N Curlat, Andrei MalkovAndrei Malkov, Svetlana B. Tsogoeva
The application of a convenient one-pot synthetic strategy, utilizing an in situ formed organocatalyst, to the enantioselective synthesis of anti-leukaemia agent (R)-convolutamydine A has been demonstrated.
S.B.T is grateful to the Interdisciplinary Center for Molecular Materials (ICMM), Erlangen Catalysis Resource Center (ECRC) and Deutsche Forschungsgemeinschaft (DFG) for research support. S.B.T. and F.Z.M. acknowledge financial support from the BMBF and AȘM (bilateral BMBF-AȘM project Ref. № MDA 08/010 and № 09.820.05.08 GF).