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Organocatalytic asymmetric domino Michael-Henry reaction for the synthesis of substituted bicyclo[3.2.1]octan-2-ones
journal contribution
posted on 2015-07-28, 07:36 authored by Michail Tsakos, Mark ElsegoodMark Elsegood, Christoforos G KokotosThe first organocatalytic asymmetric reaction between 1,4-cyclohexanedione and nitroalkenes have been studied, affording bicyclo[3.2.1]octane derivatives containing four continuous stereogenic centres. The products were obtained through a domino Michael-Henry process as a single diastereoisomer with excellent enantioselectivities.
History
School
- Science
Department
- Chemistry
Published in
CHEMICAL COMMUNICATIONSVolume
49Issue
22Pages
2219 - 2221 (3)Citation
TSAKOS, M., ELSEGOOD, M.R.J. and KOKOTOS, C.G., 2013. Organocatalytic asymmetric domino Michael-Henry reaction for the synthesis of substituted bicyclo[3.2.1]octan-2-ones. Chemical Communications, 49 (22), pp.2219-2221Publisher
© Royal Society of ChemistryVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2013Notes
This paper was submitted for publication in the journal "Chemical Communications" and the definitive version can be found at: http://dx.doi.org/10.1039/c3cc39165eISSN
1359-7345Publisher version
Language
- en