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Overview and use of tools for selecting modelling techniques in health economic studies

journal contribution
posted on 28.05.2021, 08:24 by Huajie Jin, Stewart Robinson, Wenru Shang, Evanthia Achilla, David Aceituno, Sarah Byford
The availability and use of tools to guide the choice of modelling technique are not well understood. Our study aims to review existing tools and explore the use of those tools in health economic models. Two reviews and one case study were conducted. Review 1 aimed to identify tools based on expert opinion and citation searching and explore the value of the tools for health economic models. Review 2, based on citation searching, aimed to describe how those tools have been used in health economic models. Both reviews were conducted using Web of Science and Scopus. Two independent reviewers selected studies for inclusion. A case study, focused on economic evaluations of antipsychotic medication in schizophrenia, was conducted to compare the modelling techniques used by existing models with modelling techniques recommended by identified tools. Seven tools were identified, of which the revised Brennan's toolkit, was assessed to be the most appropriate for health economic models. The seven tools were cited 126 times in publications reporting health economic models. Only 17 of these (13.5%) reported that they used the tool(s) to guide the choice of modelling technique. Application of these tools suggested discrete event simulation is most appropriate for modelling antipsychotic medication in schizophrenia, but discrete event simulation was only used by 17% of existing models. There is considerable inconsistency between the modelling techniques used by existing models and modelling techniques recommended by tools. It is recommended that for future modelling studies the choice of modelling technique should be justified, this can be achieved by the application of model selection tools, such as the revised Brennan's toolkit. Future research is required to explore the barriers to using model selection tools in health economic models and to update existing tools and make them easier to use.

History

School

  • Business and Economics

Department

  • Business

Published in

PharmacoEconomics

Volume

39

Issue

7

Pages

757-770

Publisher

Springer Science and Business Media LLC

Version

AM (Accepted Manuscript)

Rights holder

© The Authors

Publisher statement

This is a post-peer-review, pre-copyedit version of an article published in PharmacoEconomics. The final authenticated version is available online at: https://doi.org/10.1007/s40273-021-01038-1

Acceptance date

12/04/2021

Publication date

2021-05-20

Copyright date

2021

ISSN

1170-7690

eISSN

1179-2027

Language

en

Depositor

Prof Stewart Robinson. Deposit date: 27 May 2021

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