PLGA degradation Gilda Colloids + Surfaces.pdf (1.42 MB)
Download filePLGA particle production for water soluble drug encapsulation: degradation and release behaviour
journal contribution
posted on 2009-12-11, 14:27 authored by G. Gasparini, Richard Holdich, S.R. KosvintsevParticles for subcutaneous depot use encapsulating a model water soluble
drug have been produced from poly(lactic-glycolic acid) (PLGA) using a
membrane emulsification – solvent evaporation technique. The release
behaviour, mainly the change in size and inner morphology are reported.
During release, the particles initially swelled in size, then reduced. A diffusion
based model, taking in to account the change in particle size, is presented.
Surface erosion is evident from the particle size and image evidence, and the
diffusion model provides a fit to the data even during the surface erosion
period, suggesting that the model drug diffuses before the particle degrades.
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