PON1 gene polymorphisms and CAD.pdf (303.47 kB)
Paraoxonase 1 gene polymorphisms (Q192R and L55M) are associated with coronary artery disease susceptibility in Asian Indians
journal contribution
posted on 2018-11-30, 14:59 authored by Sumanpreet Kaur, Gurjit Kaur Bhatti, Rajesh Vijayvergiya, Puneetpal Singh, Sarabjit MastanaSarabjit Mastana, Rupinder Tewari, Jasvinder Singh BhattiBackground: Coronary artery disease (CAD) is a complex
metabolic disorder in which lifestyle and genetic factors are
known to play key roles in pathogenesis. The paraoxonase 1
(PON1) enzyme has a defensive effect against CAD progression,
as it safeguards low-density lipoproteins (LDLs) from
oxidative modifications. The most extensively studied genetic
variants in the PON1 gene are Q192R and L55M, which
have been related with LDL antioxidative activity and risk of
CAD. Objective: The present case-control study intended to
examine the Q192R and L55M polymorphisms and their association
with the risk of CAD patients in north Indians.
Methods: A total of 872 subjects (412 CAD patients and 460
controls) were recruited from north India. The PON1 gene
was amplified and genotypes were studies using PCR-RFLP.
χ2 analysis was performed to compare genotype/allele frequencies
in patients and controls. Results: The present study indicated abdominal obesity, elevated body mass index, and
dyslipidemia with increased levels of total cholesterol and
triglycerides as well as reduced high-density lipoprotein
cholesterol in CAD subjects compared to healthy controls
(p < 0.05). Logistic regression analysis of the data revealed an
association of the RR genotype of the Q192R polymorphism
with an about 2-fold elevated risk of CAD (OR = 2.23, 95%
CI = 1.47–3.37, p = 0.0001). Contrariwise, the L55M polymorphism
did not show significant association with CAD (OR =
1.81, 95% CI = 0.66–4.95, p = 0.326). Conclusions: The Q192R
polymorphism in the PON1 gene may be a susceptibility
gene associated with increased risk of CAD in an Asian Indian
population.
Funding
This study was financially supported by University Grants Commission (UGC), New Delhi under a Maulana Azad National Fellowship awarded to S. Kaur.
History
School
- Sport, Exercise and Health Sciences
Published in
International Journal of Diabetes and MetabolismVolume
21Pages
38 - 47Citation
KAUR, S. ... et al., 2018. Paraoxonase 1 gene polymorphisms (Q192R and L55M) are associated with coronary artery disease susceptibility in Asian Indians. International Journal of Diabetes and Metabolism, 21, pp. 38-47.Publisher
© the Authors. Published by Karger PublishersVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2018-10-12Publication date
2018-11-27Notes
This is an Open Access Article. It is published by Karger under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/ISSN
1606-7754Publisher version
Language
- en