Bishop et al Participant acceptability of exercise in kidney disease BMJ Open 2017.pdf (1.31 MB)
Participant acceptability of exercise in kidney disease (PACE-KD): a feasibility study protocol in renal transplant recipients
journal contribution
posted on 2017-09-27, 09:58 authored by Nicolette BishopNicolette Bishop, Roseanne Billany, Alice C. SmithIntroduction Cardiovascular disease (CVD) is a major cause of mortality in renal transplant recipients (RTRs). General population risk scores for CVD underestimate the risk in patients with chronic kidney disease (CKD) suggesting additional non-traditional factors. Renal
transplant recipients also exhibit elevated inflammation and impaired immune function. Exercise has a positive impact on these factors in patients with CKD but there is a lack of rigorous research in RTRs, particularly surrounding the feasibility and acceptability of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) in this population. This study aims to explore the feasibility of three different supervised aerobic exercise programmes in RTRs to guide the design of future large-scale efficacy studies.
Methods and analysis Renal transplant recipients will be randomised to HIIT A (16min interval training with 4, 2 and
1min intervals at 80%–90% of peak oxygen uptake (VO2 peak)), HIIT B (4×4min interval training at 80%–90% VO2peak)
or MICT (~40min cycling at 50%–60% VO2peak) where they will undertake 24 supervised sessions (approximately
thrice weekly over 8 weeks). Assessment visits will be at baseline, midtraining, immediate post-training and 3 months post-training. The study will evaluate the feasibility of recruitment, randomisation, retention, assessment procedures and the implementation of the interventions.
A further qualitative sub-study QPACE-KD (Qualitative Participant Acceptability of Exercise in Kidney Disease) will explore patient experiences and perspectives through semistructured interviews and focus groups. Ethics and dissemination All required ethical and regulatory approvals have been obtained. Findings will be
disseminated through conference presentations, public platforms and academic publications. Trial registration number Prospectively registered; ISRCTN17122775
Funding
This study is jointly funded by Heart Research UK grant number RG2650/15/18, the Stoneygate Trust and the Engineering and Physical Sciences Research Council (EPSRC) Antimicrobial Resistance (AMR) grant. The research was supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre.
History
School
- Sport, Exercise and Health Sciences
Published in
BMJ OpenVolume
7Citation
BISHOP, N., BILLANY, R. and SMITH, A.C., 2017. Participant acceptability of exercise in kidney disease (PACE-KD): a feasibility study protocol in renal transplant recipients. BMJ Open, 7 (9), e017494.Publisher
BMJ Publishing © Article author(s)Version
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/Acceptance date
2017-07-14Publication date
2017-09-24Copyright date
2017Notes
This is an Open Access Article. It is published by BMJ Publishing under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/ISSN
2044-6055Publisher version
Language
- en