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Pharmaceutical particles design by membrane emulsification: preparation methods and applications in drug delivery

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journal contribution
posted on 19.06.2017, 10:04 by Emma Piacentini, Marijana DragosavacMarijana Dragosavac, L. Giorno
© 2017 Bentham Science Publishers.Nowadays, the rational design of particles is an important issue in the development of pharmaceutical medicaments. Advances in manufacturing methods are required to design new pharmaceutical particles with target properties in terms of particle size, particle size distribution, structure and functional activity. Membrane emulsification is emerging as a promising tool for the production of emulsions and solidified particles with tailored properties in many fields. In this review, the current use of membrane emulsification in the production of pharmaceutical particles is highlighted. Membrane emulsification devices designed for small-scale testing as well as membrane-based methods suitable for large-scale production are discussed. A special emphasis is put on the important factors that contribute to the encapsulation efficiency and drug loading. The most recent studies about the utilization of the membrane emulsification for preparing particles as drug delivery systems for anticancer, proteins/peptide, lipophilic and hydrophilic bioactive drugs are reviewed.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Current Pharmaceutical Design

Volume

23

Issue

2

Pages

302 - 318

Citation

PIACENTINI, E., DRAGONSAVAC, M.M. and GIORNO, L., 2017. Pharmaceutical particles design by membrane emulsification: preparation methods and applications in drug delivery. Current Pharmaceutical Design, 23(2), pp. 302-318.

Publisher

© Bentham Science Publishers

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2017

Notes

The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1381612823666161117160940.

ISSN

1381-6128

eISSN

1873-4286

Language

en

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