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Photo-polymerisable electrospun fibres of N-methacrylate glycol chitosan for biomedical applications

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posted on 21.05.2015, 13:46 by Ilaria Romano, Elisa MeleElisa Mele, Jose A. Heredia-Guerrero, Luca Ceseracciu, Hadi Hajiali, Luca Goldoni, Lara Marini, Athanassia Athanassiou
The availability of nanofibrous substrates with engineered properties, such as controlled porosity, mechanical conformability, biodegradation profile and drug release, is of strategic importance in the biomedical sector. Here, we demonstrate that N-methacrylate glycol chitosan, a photo-polymerisable, biocompatible and water-soluble derivative of chitosan, can be easily processed to create non-woven mats of nanofibres with controlled physicochemical characteristics. The produced fibrous mats are characterised by thermal stability, Young's modulus of 140 MPa and ultimate strength of 4 MPa. The degree of cross-linking of the realised fibres regulates their durability and degradation profile under conditions of high humidity, but also allows controlling the delivery over time of active agents encapsulated inside the fibres. We demonstrate that the N-methacrylate glycol chitosan nanofibres are able to release an antimicrobial drug within 24 hours. Moreover, cells proliferation of 85% indicates that non-cytotoxic substances were released from the electrospun mats.

Funding

Jose A. Heredia-Guerrero is supported by a Marie Curie IntraEuropean Fellowship (BIOPROTO project), financed by the EU's Seventh Framework Programme for Research (FP7).

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

RSC ADVANCES

Volume

5

Issue

31

Pages

24723 - 24728 (6)

Citation

ROMANO, I. ... et al., 2015. Photo-polymerisable electrospun fibres of N-methacrylate glycol chitosan for biomedical applications. RSC Advances, 5 (31), pp. 24723 - 24728.

Publisher

© Royal Society of Chemistry

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2015

Notes

This article was published in the journal RSC Advances [© Royal Society of Chemistry] and the definitive version is available at: http://dx.doi.org/10.1039/c5ra02301g

ISSN

2046-2069

Language

en