Physical activity measured by accelerometry and its associations with cardiac structure and vascular function in young and middle-aged adults.pdf (378.99 kB)
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Physical activity measured by accelerometry and its associations with cardiac structure and vascular function in young and middle-aged adults

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posted on 30.03.2016, 11:26 authored by Charlotte Andersson, Asya Lyass, Martin G. Larson, Nicole L. Spartano, Joseph A. Vita, Emelia J. Benjamin, Joanne M. Murabito, Dale EsligerDale Esliger, Susan J. Blease, Naomi M. Hamburg, Gary F. Mitchell, Ramachandran S. Vasan
Background Physical activity is associated with several health benefits, including lower cardiovascular disease risk. The independent influence of physical activity on cardiac and vascular function in the community, however, has been sparsely investigated. Measures and Results We related objective measures of moderate‐ to vigorous‐intensity physical activity (MVPA, assessed by accelerometry) to cardiac and vascular indices in 2376 participants of the Framingham Heart Study third generation cohort (54% women, mean age 47 years). Using multivariable regression models, we related MVPA to the following echocardiographic and vascular measures: left ventricular mass, left atrial and aortic root sizes, carotid–femoral pulse wave velocity, augmentation index, and forward pressure wave. Men and women engaged in MVPA 29.9±21.4 and 25.5±19.4 min/day, respectively. Higher values of MVPA (per 10‐minute increment) were associated with lower carotid–femoral pulse wave velocity (estimate −0.53 ms/m; P=0.006) and lower forward pressure wave (estimate −0.23 mm Hg; P=0.03) but were not associated with augmentation index (estimate 0.13%; P=0.25). MVPA was associated positively with loge left ventricular mass (estimate 0.006 loge [g/m2]; P=0.0003), left ventricular wall thickness (estimate 0.07 mm; P=0.0001), and left atrial dimension (estimate 0.10 mm; P=0.01). MVPA also tended to be positively associated with aortic root dimension (estimate 0.05 mm; P=0.052). Associations of MVPA with cardiovascular measures were similar, in general, for bouts lasting <10 versus ≥10 minutes. Conclusions In our community‐based sample, greater physical activity was associated with lower vascular stiffness but with higher echocardiographic left ventricular mass and left atrial size. These findings suggest complex relations of usual levels of physical activity and cardiovascular remodeling.

Funding

This study was funded by the NIH Heart, Lung and Blood Institute (contract #N01-HC-25195, PI, Vasan) with additional support from 1R01AG047645 (PI, Vasan), and Evans Scholar award from the department of Medicine, Boston University School of Medicine (PI, Vasan).

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of the American Heart Association

Volume

4

Issue

3

Citation

ANDERSSON, C. ... et al, 2015. Physical activity measured by accelerometry and its associations with cardiac structure and vascular function in young and middle-aged adults. Journal of the American Heart Association, 4 (3), e001528.

Publisher

Wiley Blackwell on behalf of the American Heart Association / © The Authors

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/

Acceptance date

17/02/2015

Publication date

2015-03-19

Notes

This is an open access article distributed under the terms of the Creative Commons Attribution‐NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

ISSN

2047-9980

Language

en

Article number

e001528