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Physical frailty and cognitive status over-60 age populations: a systematic review with meta-analysis

journal contribution
posted on 24.09.2018, 15:32 by Guilherme Eustaquio Furtado, Adriana Caldo, Tais Rieping, Edith Filaire, Eef Hogervorst, Ana Maria Teixeira, Jose Pedro Ferreira
The aim of this meta-analysis was to analyse the magnitude of the effect-size of the cognitive status of populations over 60 years of age, when comparing nonfrail versus pre-frail and nonfrail versus frail subgroups. A systematic review of prospective studies published from 2000 to 2017 was completed in Medline, B-on, Ebsco, Ebsco Health, Scielo, ERIC, LILACS and Sport discus databases and observational, cohort and cross-sectional studies were selected. The Mini-Mental State Examination to screening cognitive status and the Fried phenotype for assess physical frailty state was used as clinical outcomes. After applying additional search criteria, 14 manuscripts (26,798 old participants) were selected from an initial universe of 1681 identified. When comparing the scores of cognitive status of the participants who were non-frail (n = 12,729, 47.4%) versus pre-frail (n = 11,559, 43.2%) and non-frail versus frail (n = 2452, 9.4%) subgroups, significant statistical differences were found for both comparisons (M ± SD = 0.60, 95%CI: 0.50-0.62, p < 0.001 and M ± SD = 3.43, 95%CI: 2.26–4.60, p < 0.001, respectively). It is clear that poor cognitive function is strongly closed associated with pre-frailty and frailty subgroups in older populations around the world.


This systematic review was integrated as a research project entitled “PRO-HMESCI: Hormonal mediation of exercise on cognition, stress and immunity” [FCT PTDC/DTP-DES/0154/2012] study protocol (Teixeira et al., 2016). Furtado (PhD student) were financed by a grant from CAPES/CNPQ – Ministry of Education – Brazil, reference BEX: 11929/13-8. Ana Teixeira and Jose Ferreira are registered at CIDAF (UID/PTD/04213/2016).



  • Sport, Exercise and Health Sciences

Published in

Archives of Gerontology and Geriatrics




240 - 248


FURTADO, G.E. ... et al, 2018. Physical frailty and cognitive status over-60 age populations: a systematic review with meta-analysis. Archives of Gerontology and Geriatrics, 78, pp.240-248.


© Elsevier


SMUR (Submitted Manuscript Under Review)

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