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Physiological complexity: influence of ageing, disease and neuromuscular fatigue on muscle force and torque fluctuations

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posted on 2021-11-22, 14:25 authored by Jamie Pethick, Sam WinterSam Winter, Mark Burnley
New Findings: What is the topic of this review? Physiological complexity in muscle force and torque fluctuations, specifically the quantification of complexity, how neuromuscular complexityis altered by perturbations and the potential mechanism underlying changes in neuromuscular complexity. What advances does it highlight? The necessity to calculate both magnitude- and complexity-based measures for the thorough evaluation of force/torque fluctuations. Also the need for further research on neuromuscular complexity, particularly how it relates to the performance of functional activities (e.g. manual dexterity, balance, locomotion). Abstract: Physiological time series produce inherently complex fluctuations. In the last 30 years, methods have been developed to characterise these fluctuations, and have revealed that they contain information about the function of the system producing them. Two broad classes of metrics are used: (1) those which quantify the regularity of the signal (e.g. entropy metrics); and (2) those which quantify the fractal properties of the signal (e.g. detrended fluctuation analysis). Using these techniques, it has been demonstrated that ageing results in a loss of complexity in the time series of a multitude of signals, including heart rate, respiration, gait and, crucially, muscle force or torque output. This suggests that as the body ages, physiological systems become less adaptable (i.e. the systems’ ability to respond rapidly to a changing external environment is diminished). More recently, it has been shown that neuromuscular fatigue causes a substantial loss of muscle torque complexity, a process that can be observed in a few minutes, rather than the decades it requires for the same system to degrade with ageing. The loss of torque complexity with neuromuscular fatigue appears to occur exclusively above the critical torque (at least for tasks lasting up to 30 min). The loss of torque complexity can be exacerbated with previous exercise of the same limb, and reduced by the administration of caffeine, suggesting both peripheral and central mechanisms contribute to this loss. The mechanisms underpinning the loss of complexity are not known but may be related to altered motor unit behaviour as the muscle fatigues.

Funding

Leverhulme Trust. Grant Number: RPG-2016-440

History

School

  • Sport, Exercise and Health Sciences

Published in

Experimental Physiology

Volume

106

Issue

10

Pages

2046 - 2059

Publisher

Wiley

Version

  • AM (Accepted Manuscript)

Rights holder

© The Authors. Experimental Physiology © The Physiological Society

Publisher statement

This is the peer reviewed version of the following article: PETHICK, J., WINTER, S. and BURNLEY, M., 2021. Physiological complexity: influence of ageing, disease and neuromuscular fatigue on muscle force and torque fluctuations. Experimental Physiology, 106 (10), pp.2046-2059, which has been published in final form at https://doi.org/10.1113/EP089711. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

Acceptance date

2021-08-26

Publication date

2021-09-14

Copyright date

2021

ISSN

0958-0670

eISSN

1469-445X

Language

  • en

Depositor

Dr Sam Winter. Deposit date: 21 November 2021

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