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Plasma free fatty acids metabolic profile with LC-MS and appetite-related hormones in South Asian and white European men in relation to adiposity, physical activity and cardiorespiratory fitness: a cross sectional study
journal contribution
posted on 2019-04-12, 08:53 authored by Simone Benedetti, Naser F. Al-Tannak, Mansour Alzharani, Hannah J. Moir, David StenselDavid Stensel, Alice ThackrayAlice Thackray, Declan Naughton, Mehmet T. Dorak, Owen Spendiff, Natasha Hill, David G Watson, Judith E. AllgroveSouth Asians have a greater cardiovascular disease (CVD) and type 2 diabetes (T2D) risk
than white Europeans, but the mechanisms are poorly understood. This study examined ethnic
differences in free fatty acids (FFAs) metabolic profile (assessed using liquid chromatography-mass
spectrometry), appetite-related hormones and traditional CVD and T2D risk markers in blood
samples collected from 16 South Asian and 16 white European men and explored associations with
body composition, objectively-measured physical activity and cardiorespiratory fitness. South Asians
exhibited higher concentrations of five FFAs (laurate, myristate, palmitate, linolenic, linoleate;
P≤0.040), lower acylated ghrelin (ES=1.00, P=0.008) and higher leptin (ES=1.11, P=0.004) than white
Europeans; total peptide YY was similar between groups (P=0.381). South Asians exhibited elevated
fasting insulin, C-reactive protein, interleukin-6, triacylglycerol and ratio of total cholesterol to high density lipoprotein cholesterol (HDL-C) and lower fasting HDL-C (all ES≥0.74, P≤0.053). Controlling
for body fat percentage (assessed using air displacement plethysmography) attenuated these
differences. Despite similar habitual moderate-to-vigorous physical activity (ES=0.18, P=0.675),
V̇ O2max was lower in South Asians (ES=1.36, P=0.001). Circulating FFAs in South Asians were
positively correlated with body fat percentage (r2=0.92), body mass (r2 =0.86) and AUC glucose
(r2=0.89) whereas in white Europeans FFAs were negatively correlated with total step counts (r2 =0.96).
In conclusion, South Asians exhibited a different FFA profile, lower ghrelin, higher leptin, impaired
CVD and T2D risk markers and lower cardiorespiratory fitness than white Europeans
Funding
This research was co-funded by the School of Life Sciences, Pharmacy & Chemistry, Kingston University (London, UK) and by the NIHR Leicester Biomedical Research Centre (Leicester, UK).
History
School
- Sport, Exercise and Health Sciences
Published in
MetabolitesVolume
9Issue
4Pages
71Citation
BENEDETTI, S. ... et al., 2019. Plasma free fatty acids metabolic profile with LC-MS and appetite-related hormones in South Asian and white European men in relation to adiposity, physical activity and cardiorespiratory fitness: a cross sectional study. Metabolites, 9(4), 71.Publisher
© The Authors. Published by MDPI AGVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/Acceptance date
2019-04-11Publication date
2019-04-13Notes
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).ISSN
2218-1989Publisher version
Language
- en