Manuscript file_revised version_15.07.2019.pdf (1.85 MB)

Poly(4-vinylaniline)/polyaniline bilayer functionalized bacterial cellulose for flexible electrochemical biosensors

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journal contribution
posted on 19.07.2019, 12:57 by Ana M. Rodrigues Rebelo, Changqing Liu, Karl-Herbert Schafer, Monika Saumer, Guang Yang, Yang Liu
Bacterial cellulose (BC) nanofibril network is modified with an electrically conductive polyvinylaniline/polyaniline (PVAN/PANI) bilayer for construction of potential electrochemical biosensors. This is accomplished through surface-initiated atom transfer radical polymerization of 4-vinylaniline, followed by in situ chemical oxidative polymerization of aniline. A uniform coverage of BC nanofiber with 1D supramolecular PANI nanostructures is confirmed by FTIR, XRD and CHN elemental analysis. Cyclic voltammograms evince the switching in the electrochemical behavior of BC/PVAN/PANI nanocomposites from the redox peaks at 0.74 V, in the positive scan and at -0.70 V, in the reverse scan, (at 100 mV.s-1 scan rate). From these redox peaks, PANI is the emeraldine form with the maximal electrical performance recorded, showing charge-transfer resistance as low as 21 Ω and capacitance as high as 39 μF. The voltage-sensible nanocomposites can interact with neural stem cells (NSCs) isolated from subventricular zone (SVZ) of the brain, through stimulation and characterization of differentiated SVZ cells into specialized and mature neurons with long neurites measuring up to 115±24 μm length after 7 days of culture without visible signs of cytotoxic effects. The findings pave the path to the new effective nanobiosensor technologies for nerve regenerative medicine, which demands both electroactivity and biocompatibility.

Funding

This research was supported by a Marie Curie International Research Staff Exchange Scheme Project of the 7th European Community Framework Program (Grant No. PIRSES-GA-2010-269113), entitled “Micro-Multi-Material Manufacture to Enable Multifunctional Miniaturized Devices (M6)”.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Langmuir

Volume

35

Issue

32

Pages

10354-10366

Citation

REBELO, A.M.R. .... et al., 2019. Poly(4-vinylaniline)/polyaniline bilayer functionalized bacterial cellulose for flexible electrochemical biosensors. Langmuir, 35 (32), pp.10354-10366.

Publisher

© American Chemical Society (ACS)

Version

AM (Accepted Manuscript)

Publisher statement

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.langmuir.9b01425.

Acceptance date

16/07/2019

Publication date

2019-07-18

Copyright date

2019

ISSN

0743-7463

eISSN

1520-5827

Language

en

Exports