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Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine

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journal contribution
posted on 25.03.2014, 13:35 by Atul Nayak, Diganta DasDiganta Das
There has been an increasing interest in applying biotechnology in formulating and characterising new and innovative drug delivery methods, e.g., drug-loaded biodegradable microneedles within the area of transdermal delivery technology. Recently, microneedles have been proposed for use in pain management, e.g., post-operative pain management through delivery of a local anaesthetic, namely, lidocaine. Lidocaine is a fairly common, marketed prescription-based, local anaesthetic pharmaceutical, applied for relieving localised pain and lidocaineloaded microneedles have been explored. The purpose of this review is to evaluate the properties of biodegradable polymers that may allow the preparation of microneedle systems, methods of preparing them and pharmacokinetic conditions in considering the potential use of lidocaine for delivery through the skin.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

NAYAK, A. and DAS, D.B., 2013. Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine. Biotechnology Letters, 35 (9), pp. 1351 - 1363.

Publisher

© Springer Science+Business Media

Version

AM (Accepted Manuscript)

Publication date

2013

Notes

This article was published in the journal Biotechnology Letters [© Springer Science+Business Media]. The definitive version is available at: http://dx.doi.org/10.1007/s10529-013-1217-3

ISSN

0141-5492

Language

en