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Precision manufacturing for clinical-quality regenerative medicines

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posted on 24.06.2014 by David Williams, Rob Thomas, Paul Hourd, Amit Chandra, Elizabeth Ratcliffe, Yang Liu, Erin Rayment, J. Richard Archer
Innovations in engineering applied to healthcare make a significant difference to people's lives. Market growth is guaranteed by demographics. Regulation and requirements for good manufacturing practice—extreme levels of repeatability and reliability—demand high-precision process and measurement solutions. Emerging technologies using living biological materials add complexity. This paper presents some results of work demonstrating the precision automated manufacture of living materials, particularly the expansion of populations of human stem cells for therapeutic use as regenerative medicines. The paper also describes quality engineering techniques for precision process design and improvement, and identifies the requirements for manufacturing technology and measurement systems evolution for such therapies.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Volume

370

Issue

1973

Pages

3924 - 3949 (26)

Citation

WILLIAMS, D.J. ... et al, 2012. Precision manufacturing for clinical-quality regenerative medicines. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 370 (1973), pp. 3924 - 3949.

Publisher

© The Royal Society

Version

SMUR (Submitted Manuscript Under Review)

Publication date

2012

Notes

This article was published in the journal, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences [© The Royal Society]. The definitive version is available at: http://dx.doi.org/10.1098/rsta.2011.0049

ISSN

1364-503X

Language

en

Location

Royal Soc, London, ENGLAND

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