Royal Society Manuscript - Precision Manufacturing of Regenerative Medicines - Williams et al.pdf (907.71 kB)
Precision manufacturing for clinical-quality regenerative medicines
journal contribution
posted on 2014-06-24, 12:08 authored by David Williams, Rob ThomasRob Thomas, Paul Hourd, Amit Chandra, Elizabeth RatcliffeElizabeth Ratcliffe, Yang LiuYang Liu, Erin Rayment, J. Richard ArcherInnovations in engineering applied to healthcare make a significant difference to people's lives. Market growth is guaranteed by demographics. Regulation and requirements for good manufacturing practice—extreme levels of repeatability and reliability—demand high-precision process and measurement solutions. Emerging technologies using living biological materials add complexity. This paper presents some results of work demonstrating the precision automated manufacture of living materials, particularly the expansion of populations of human stem cells for therapeutic use as regenerative medicines. The paper also describes quality engineering techniques for precision process design and improvement, and identifies the requirements for manufacturing technology and measurement systems evolution for such therapies.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCESVolume
370Issue
1973Pages
3924 - 3949 (26)Citation
WILLIAMS, D.J. ... et al, 2012. Precision manufacturing for clinical-quality regenerative medicines. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 370 (1973), pp. 3924 - 3949.Publisher
© The Royal SocietyVersion
- SMUR (Submitted Manuscript Under Review)
Publication date
2012Notes
This article was published in the journal, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences [© The Royal Society]. The definitive version is available at: http://dx.doi.org/10.1098/rsta.2011.0049ISSN
1364-503XPublisher version
Language
- en