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Production of streptomycin from chitin using Streptomyces griseus in bioreactors of different configuration
journal contributionposted on 2008-07-08, 11:48 authored by Richard J.L. Meanwell, Gilbert Shama
Streptomyces griseus was cultured in three different bioreactors in a medium containing chitin flakes. When a conventional bioreactor stirred by two sets of Rushton impellers and operated at high speed was used, the yield of streptomycin (3.1 mg/l) was the highest observed and occurred at approximately 500 hours. Cultivation of S. griseus in a bioreactor stirred at low speed by a U-shaped paddle resulted in a lower yield of streptomycin (1.8 mg/l) but this was achieved in a shorter period of time (400 hours). Increasing the concentration of chitin from 5 to 10 % w/v had no significant effect on either of these two parameters. The use of a novel vertical basket bioreactor in which the chitin flakes were contained within a wire mesh basket and were gently fluidised by air, enabled comparatively high yields of streptomycin (2.8 mg/l) in the relatively short time of 300 hours.
- Aeronautical, Automotive, Chemical and Materials Engineering
- Chemical Engineering
CitationMEANWELL, R.J.L. and SHAMA, G., 2008. Production of streptomycin from chitin using Streptomyces griseus in bioreactors of different configuration. Bioresource technology, 99(13), pp.5634-5639
NotesThis is a journal article. It was published in the Bioresource technology [© Elsevier]. The definitive version is available at: doi:10.1016/j.biortech.2007.10.036