3D fluid separator_R1-MPYD_Submit.pdf (3.12 MB)
Download fileProgress towards the design and numerical analysis of a 3D microchannel biochip separator
journal contribution
posted on 2013-10-21, 08:57 authored by Xiangdong Xue, Silvia Marson, Mayur K. Patel, Chris Bailey, William P. O'Neill, David Topham, Robert Kay, Marc P.Y. DesmulliezThis paper reports the design and numerical analysis of a three-dimensional biochip plasma blood
separator using Computational Fluid Dynamics (CFD) techniques. Based on the initial
configuration of a 2D separator, five 3D microchannel biochip designs are categorically developed
through axial and plenary symmetrical expansions. These include the geometric variations of three
types of the branch side channels (circular, rectangular, disc) and two types of the main channel
(solid and concentric). Ignoring the initial transient behaviour and assuming that steady state flow
has been established, the behaviour of the blood fluid in the devices is algebraically analysed and
numerically modelled. The roles of the relevant microchannel mechanisms, i.e. bifurcation,
constriction and bending channel, on promoting the separation process are analysed based on
modelling results. The differences among the different 3D implementations are compared and
discussed. The advantages of 3D over 2D separator in increasing separation volume and effectively
depleting cell-free layer fluid from the whole cross section circumference are addressed and
illustrated.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Citation
XUE, X. ... et al, 2011. Progress towards the design and numerical analysis of a 3D microchannel biochip separator. International Journal for Numerical Methods in Biomedical Engineering, 27 (11), pp.1771–1792.Publisher
© John Wiley & Sons Ltd.Version
- SMUR (Submitted Manuscript Under Review)
Publication date
2011Notes
This is the pre-peer reviewed version of the article which has been published in final form at: http://dx.doi.org/10.1002/cnm.1439ISSN
2040-7947Publisher version
Language
- en