Psychdistress_infectious disease combined.pdf (230.6 kB)
Psychological distress and infectious disease mortality in the general population
journal contributionposted on 2019-01-09, 09:06 authored by Mark Hamer, Mika Kivimaki, Emmanuel Stamatakis, G. David Batty
There is a paucity of studies examining the relation between high psychological distress and infectious disease in the general population. We examined this association in a large multi-cohort study drawn from the general population. The analytic sample comprised 104,923 men and women (age, 47.3 ± 17.4 year; 45.7% men) in which psychological distress symptoms was assessed using the 12-item version of the General Health Questionnaire. There were 1535 deaths attributed to infectious diseases during 971,220 person-years of follow up (mean 9.3; range 0.1–17.1 years). A dose-response association between GHQ-12 score and all infectious disease mortality was observed after adjusting for age, sex, survey year, occupational social class, longstanding illness, smoking, alcohol, and physical activity (per SD increase, hazard ratio = 1.24; 95% CI, 1.20–1.28). A similar pattern was apparent for viral infections (1.23; 1.14, 1.33) and pneumonia (1.20; 1.13, 1.28), but weaker for bacterial infections (1.09; 1.00, 1.19). In conclusion, psychological distress is associated with higher risk of infectious disease.
- Sport, Exercise and Health Sciences
Published inBrain, Behavior, and Immunity
CitationHAMER, M. ... et al, 2018. Psychological distress and infectious disease mortality in the general population. Brain, Behavior, and Immunity, 76, pp.280-283.
- AM (Accepted Manuscript)
Publisher statementThis paper was accepted for publication in the journal Brain, Behavior, and Immunity and the definitive published version is available at https://doi.org/10.1016/j.bbi.2018.12.011