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Pulling a folded polymer through a nanopore

journal contribution
posted on 2021-03-22, 14:24 authored by Bappa Ghosh, Jalal Sarabadani, Srabanti Chaudhury, Tapio Ala-NissilaTapio Ala-Nissila
We investigate the translocation dynamics of a folded linear polymer which is pulled through a nanopore by an external force. To this end, we generalize the iso-flux tension propagation theory for end-pulled polymer translocation to include the case of two segments of the folded polymer traversing simultaneously trough the pore. Our theory is extensively benchmarked with corresponding molecular dynamics (MD) simulations. The translocation process for a folded polymer can be divided into two main stages. In the first stage, both branches are traversing the pore and their dynamics is coupled. If the branches are not of equal length, there is a second stage where translocation of the shorter branch has been completed. Using the assumption of equal monomer flux of both branches confirmed by MD simulations, we analytically derive the equations of motion for both branches and characterize the translocation dynamics in detail from the average waiting time and its scaling form.

Funding

DAE-BRNS (37(2)/14/08/2016-BRNS/37022)

IISER Pune

Academy of Finland through its PolyDyna (No. 307806)

QFT Center of Excellence Program Grants (No. 312298)

History

School

  • Science

Department

  • Mathematical Sciences

Published in

Journal of Physics: Condensed Matter

Volume

33

Issue

1

Publisher

IOP Publishing

Version

  • P (Proof)

Rights holder

© IOP Publishing

Publisher statement

This is the Accepted Manuscript version of an article accepted for publication in Journal of Physics: Condensed Matter. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1361-648x/abb687.

Acceptance date

2020-09-09

Publication date

2020-10-07

Copyright date

2021

ISSN

0953-8984

eISSN

1361-648X

Language

  • en

Depositor

Prof Tapio Ala-Nissila. Deposit date: 18 March 2021

Article number

015101

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