antioxidants-09-00221.pdf (718.97 kB)
Download filePulse wave velocity is associated with increased plasma oxLDL in ageing but not with FGF21 and habitual exercise
journal contribution
posted on 2020-03-06, 14:41 authored by Shuen Yee Lee, Stephen F Burns, Kenneth KC Ng, David StenselDavid Stensel, Liang Zhong, Frankie HY Tan, Kar Ling Chia, Kai Deng Fam, Margaret MC Yap, Kwee Poo Yeo, Eric PH Yap, Chin Leong LimFibroblast
growth factor 21 (FGF21) and adiponectin increase expression of genes involved
in antioxidant pathways, but their roles in mediating oxidative stress and
arterial stiffness with ageing and habitual exercise remain unknown. We explored
the role of the FGF21–adiponectin axis in mediating oxidative stress and
arterial stiffness with ageing and habitual exercise. Eighty age- and sex-matched healthy individuals
were assigned to younger
sedentary or active (18–36 years old,n=20
each) and older sedentary or active (45–80 years old,n=20 each) groups. Arterial stiffness was measured indirectly using
pulse wave velocity (PWV). Fasted plasma concentrations of FGF21, adiponectin
and oxidized low-density lipoprotein (oxLDL) were measured. PWV was 0.2-fold
higher and oxLDL concentration was 25.6% higher (both p<0.001) in older than younger adults, despite no difference in
FGF21 concentration (p=0.097) between
age groups. PWV (p=0.09) and oxLDL concentration (p=0.275) did not differ between activity groups but FGF21 concentration was
9% lower in active than sedentary individuals (p=0.011). Adiponectin concentration did not differ by age (p=0.642) or exercise habits (p=0.821). In conclusion, age, but not
habitual exercise, was associated with higher oxidative stress and arterial
stiffness. FGF21 and adiponectin did not differ between younger and older
adults, unlikely mediating oxidative stress and arterial stiffness in healthy
adults.
Funding
Ministry of Education Singapore Start-up Grant for Human and Metabolic disease (L0412270).
National Medical Research Council (NMRC/OFIRG/0018/2016)
History
School
- Sport, Exercise and Health Sciences