Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer
journal contributionposted on 2016-07-19, 13:58 authored by Liam HeaneyLiam Heaney, Dorota Ruszkiewicz, Kayleigh L. Arthur, Andria Hadjithekli, Clive Aldcroft, Martin Lindley, Paul Thomas, Matthew TurnerMatthew Turner, Jim ReynoldsJim Reynolds
© 2016 Future Science Ltd.Aim: Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results & methodology: Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range. Conclusion: Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time.
- Sport, Exercise and Health Sciences
Pages1325 - 1336
CitationHEANEY, L.M. ...et al., 2016. Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer. Bioanalysis, 8(13), pp. 1325-1336.
Publisher© Future Science Ltd
- AM (Accepted Manuscript)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
NotesThis paper was accepted for publication in the journal Bioanalysis and the definitive published version is available at http://dx.doi.org/10.4155/bio-2016-0045.