Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer
journal contributionposted on 19.07.2016, 13:58 authored by Liam HeaneyLiam Heaney, Dorota Ruszkiewicz, Kayleigh L. Arthur, Andria Hadjithekli, Clive Aldcroft, Martin LindleyMartin Lindley, Paul Thomas, Matthew TurnerMatthew Turner, Jim ReynoldsJim Reynolds
© 2016 Future Science Ltd.Aim: Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results & methodology: Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range. Conclusion: Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time.
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