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Download fileRecent developments in the design of rapid response cells for laser ablation-inductively coupled plasma-mass spectrometry and their impact on bioimaging applications
journal contribution
posted on 2016-02-12, 13:26 authored by Stijn J.M. Van Malderen, Amy ManaghAmy Managh, Barry L. Sharp, Frank VanhaeckeThis review covers developments in the design of Laser Ablation (LA) cells, the associated transport tubing assembly,and their coupling to Inductively Coupled Plasma-
Mass Spectrometry (ICP-MS) instrumentation.
Recent ablation cell designs have reduced the pulse response duration for a single laser shot to <10ms, using the criterion
of the full peak width at 1% of the height of the maximum signal intensity. The evolution towards these low dispersion
systems has been profoundly influenced by our understanding of processes driving the
initial dispersion, of the design aspects of the cell and tubing that influence transport-induced dispersion and transport efficiency, and of limitations imposed by the temporal resolution of ICP-MS instruments, all of which are discussed.
Rapid response LA-ICP-MS systems greatly
benefit throughput and sensitivity, which are key parameters in 2D and 3D imaging at high lateral resolution. The analysis and imaging of biological material has come to the forefront as a key application of LA-
ICP-MS. The impact of the technical developments in LA-ICP-MS systems on emerging applications, including multiplexed
metal -tagged antibody detection (for immunohistochemistry), nanoparticle and
compound hypo-and hyperaccumulation, and
(intra-) cellular /histological studies, is
also discussed.
Funding
Amy Managh acknowledges financial support through a Loughborough University Enterprise Fellowship (Engineering and Physical Sciences Research Council, Impact Acceleration Account.
History
School
- Science
Department
- Chemistry
Published in
Journal of Analytical Atomic SpectrometryVolume
31Issue
2Pages
423 - 439Citation
VAN MALDEREN, S.J.M. ...ET AL., 2016. Recent developments in the design of rapid response cells for laser ablation-inductively coupled plasma-mass spectrometry and their impact on bioimaging applications. Journal of Analytical Atomic Spectrometry, 31(2), pp. 423-439.Publisher
© Royal Society of ChemistryVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 3.0 International (CC BY 3.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by/3.0/Acceptance date
2015-11-30Publication date
2015-11-30Copyright date
2016Notes
This paper was published as Open Access under a Creative Commons Attribution 3.0 Unported Licence.ISSN
0267-9477eISSN
1364-5544Publisher version
Language
- en