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Regulation of metabolic disease-associated inflammation by nutrient sensors

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journal contribution
posted on 03.07.2018, 08:52 by Alex S. Yamashita, Thiago Belchior, Fabio S. Lira, Nicolette BishopNicolette Bishop, Barbara Wessner, Jose C. Rosa, William T. Festuccia
Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic β31 cell dysfunction. Herein we review the mechanisms by which nutrients modulate obesity associated inflammation.

Funding

Funding was provided by Sao Paulo Research Foundation (FAPESP) to ASY (#13/15825-5), TB (#15/22983-1) and to WTF (#10/52191-6 and 15/19530-5).

History

School

  • Sport, Exercise and Health Sciences

Published in

Mediators of Inflammation

Citation

YAMASHITA, A.S. ... et al, 2018. Regulation of metabolic disease-associated inflammation by nutrient sensors. Mediators of Inflammation, 2018: 8261432.

Publisher

Hindawi Publishing Corporation © The Authors

Version

NA (Not Applicable or Unknown)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

14/06/2018

Publication date

2018

Notes

This is an Open Access Article. It is published by the Hindawi Publishing Corporation under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/. This is the accepted version of the article. It will be replaced by the published version once this is available.

ISSN

0962-9351

eISSN

1466-1861

Language

en