Relating induction time and metastable zone width
journal contributionposted on 2019-07-01, 12:42 authored by Huaiyu YangHuaiyu Yang, Alastair J. Florence
© 2017 The Royal Society of Chemistry. A relation between induction time and metastable zone width in cooling crystallization has been developed based on the correlation between temperature and supersaturation with the induction time in the classical nucleation theory. By this relation, the nucleation times in linear cooling experiments and the induction times at constant temperature can be estimated from each other, i.e. estimating metastable zone widths from experimental induction times or interfacial energy and the pre-exponential factor from metastable zone widths. Ascorbic-water system, with 120 induction times and 192 metastable zone widths determined, and several systems reported in the literature, have been investigated to compare the estimated values of metastable zone width/induction time with experimental values, respectively. The estimated metastable zone widths are fairly consistent with the experimental values. The differences between experimental literature values of metastable zone widths and the estimated values using the literature induction times range from 0.1 K to 10 K with an average of 2.5 K. For two systems (paracetamol in ethanol and salicylic acid in ethyl acetate), estimated and experimental results are of very good consistency with an average uncertainty of only about 5%. More accurate extrapolations of the induction times from metastable zone widths have been investigated. The potential utilities of this approach in crystallization research and process understanding are discussed.
We acknowledge the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallization for funding, with grant ref: EP/I033459/1. W
- Aeronautical, Automotive, Chemical and Materials Engineering
- Chemical Engineering
Pages3966 - 3978
CitationYANG, H. and FLORENCE, A.J., 2017. Relating induction time and metastable zone width. CrystEngComm, 19(28), pp. 3966 - 3978.
Publisher© Royal Society of Chemistry
- AM (Accepted Manuscript)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
NotesThis paper was accepted for publication in the journal CrystEngComm and the definitive published version is available at https://doi.org/10.1039/c7ce00770a