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Remodelling of trabecular bone in human distal tibia: A model based on an in-vivo HR-pQCT study

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journal contribution
posted on 15.04.2021, 10:10 by Juan Du, Simin LiSimin Li, Vadim SilberschmidtVadim Silberschmidt
An abnormal remodelling process of bones can lead to various bone disorders, such as osteoporosis, making them prone to fracture. Simulations of load-induced remodelling of trabecular bone were used to investigate its response to mechanical signal. However, the role of mechanostat in trabecular-bone remodelling has not yet been investigated in simulations underpinned by a longitudinal in-vivo study in humans. In this work, a finite-element model based on a 6-month longitudinal in-vivo HR-pQCT study was developed and validated to investigate the effect of mechanical stimuli on bone remodelling. The simulated changes in microstructural parameters and density of trabecular bone were compared with respective experimental results. A maximum principal strain (MPS) and a maximum principal strain gradient (∇MPS) were used as mechanical signals to drive a five-stage mechanostat remodelling model, including additional over-strain and damage stages. It was found that the density distribution varied with the studied mechanical signals, along with decreasing with time levels of bone volume fraction BV/TV, trabecular thickness Tb.Th and bone surface area Tb.BS as well as increased trabecular separation Tb.Sp. Among these parameters, BV/TV and Tb.Th together with the bone remodelling parameters from the MPS model demonstrated a significant correlation with the experimental data. The developed model provides a good foundation for further development and investigation of the relationships between mechanical loading and human bone microarchitecture.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Journal of the Mechanical Behavior of Biomedical Materials

Volume

119

Publisher

Elsevier

Version

AM (Accepted Manuscript)

Rights holder

© Elsevier

Publisher statement

This paper was accepted for publication in the journal Journal of the Mechanical Behavior of Biomedical Materials and the definitive published version is available at https://doi.org/10.1016/j.jmbbm.2021.104506

Acceptance date

30/03/2021

Publication date

2021-04-14

Copyright date

2021

ISSN

1751-6161

Language

en

Depositor

Dr Simin Li. Deposit date: 14 April 2021

Article number

104506