Remote contractions to mitigate reduced persistent inward current magnitudes in motoneurons of older adults

Motor units (MUs; i.e., the alpha motoneuron and all the muscle fibres it innervates) are the fundamental elements of the neuromuscular system that transform motor commands into mechanical actions. The transformation of the activation signal from the nervous system into single muscle fibre potentials is a non-linear function comprised of excitatory and inhibitory ionotropic synaptic inputs, which are subject to neuromodulation due to monoaminergic inputs (e.g., serotonin, noradrenaline). [...]