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Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men

journal contribution
posted on 09.07.2014, 10:55 by Stuart R. Gray, M. Robinson, Myra A. Nimmo
The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL- 6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96±6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P<0.01) by 8.4±8.9 pg ml−1 (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P<0.05) by 2.7±3.9 ng ml−1 (9.6%) and 37.7±55.6 ng ml−1 (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.

History

School

  • Sport, Exercise and Health Sciences

Published in

CELL STRESS & CHAPERONES

Volume

13

Issue

2

Pages

247 - 251 (5)

Citation

GRAY, S.R., ROBINSON, M. and NIMMO, M.A., 2008. Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men. Cell Stress and Chaperones, 13 (2), pp. 247 - 251.

Publisher

Springer © Cell Stress Society International

Version

VoR (Version of Record)

Publication date

2008

Notes

Closed access.

ISSN

1355-8145

Language

en