Review of additive manufactured tissue engineering scaffolds - relationship between geometry and performance.pdf (3.61 MB)
Download file

Review of additive manufactured tissue engineering scaffolds: relationship between geometry and performance

Download (3.61 MB)
journal contribution
posted on 08.04.2019, 13:55 by Andy GleadallAndy Gleadall, Dafydd O. Visscher, Jing Yang, Daniel Thomas, Joel Segal
Material extrusion additive manufacturing has rapidly grown in use for tissue engineering research since its adoption in the year 2000. It has enabled researchers to produce scaffolds with intricate porous geometries that were not feasible with traditional manufacturing processes. Researchers can control the structural geometry through a wide range of customisable printing parameters and design choices including material, print path, temperature, and many other process parameters. Currently, the impact of these choices is not fully understood. This review focuses on how the position and orientation of extruded filaments, which sometimes referred to as the print path, lay-down pattern, or simply "scaffold design", affect scaffold properties and biological performance. By analysing trends across multiple studies, new understanding was developed on how filament position affects mechanical properties. Biological performance was also found to be affected by filament position, but a lack of consensus between studies indicates a need for further research and understanding. In most research studies, scaffold design was dictated by capabilities of additive manufacturing software rather than free-form design of structural geometry optimised for biological requirements. There is scope for much greater application of engineering innovation to additive manufacture novel geometries. To achieve this, better understanding of biological requirements is needed to enable the effective specification of ideal scaffold geometries.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Burns Trauma

Volume

6

Pages

19 - 19

Citation

GLEADALL, A. ... et al, 2018. Review of additive manufactured tissue engineering scaffolds: relationship between geometry and performance. Burns & Trauma, 6, Article 19.

Publisher

BMC © The Authors

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

30/05/2018

Publication date

2018

Notes

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

ISSN

2321-3876

Language

en

Location

England